BRN 1350216
zearalenone
CAS: 17924-92-4
Molecular Formula: C18H22O5
BRN 1350216 - Names and Identifiers
BRN 1350216 - Physico-chemical Properties
| Molecular Formula | C18H22O5 |
| Molar Mass | 318.36 |
| Density | 1.1270 (rough estimate) |
| Melting Point | 164-165°C |
| Boling Point | 377.53°C (rough estimate) |
| Specific Rotation(α) | 25546 -170.5° (c = 1.0 in CH3OH) |
| Flash Point | 6°C |
| Solubility | Soluble in ethanol and DMSO. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystalline solid |
| Merck | 13,10169 |
| BRN | 1350216 |
| pKa | 7.58±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6120 (estimate) |
| MDL | MFCD00133085 |
| Physical and Chemical Properties | Melting point 164-165°C flash point 6°C storage conditions − 20°C Merck 13,10169 |
| In vivo study | Zearalenone is frequently implicated in reproductive disorders of farm animals and occasionally in hyperoestrogenic syndromes in humans. There is evidence that ZEA and its metabolites possess oestrogenic activity in pigs, cattle and sheep. However, ZEA is of a relatively low acute toxicity after oral or interperitoneal administration in mice, rat and pig. |
BRN 1350216 - Risk and Safety
| Risk Codes | R34 - Causes burns R62 - Possible risk of impaired fertility R63 - Possible risk of harm to the unborn child R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | DM2550000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29322090 |
BRN 1350216 - Reference
| Reference Show more | 1. Liu Mingjiang, Fang Guoqing, et al. Toxicity of a transformed zearalenone product to mice [J]. Animal Husbandry and Veterinary Medicine (12). 2. Chen Wei, Gu Xinxi, Li Guangjing, Xu Ran, Gu Zilin, Chen Baojiang, Lu Haiqiang. Expression Optimization of Zearalenone Degrading Enzyme ZHD101 and Its Application in Detoxification of Corn Pulp [J]. Journal of Hebei Agricultural University, 2020,43(06):26-34. 3. Zhiming Sun, Ankang Song, Bin Wang, Gaofeng Wang, Shuilin Zheng,Adsorption behaviors of aflatoxin B1 and zearalenone by organo-rectorite modified with quaternary ammonium salts,Journal of Molecular Liquids,Volume 264,2018,Pages 645-651,ISSN 0167-7322 4. He, Baoshan, and Xiaoze Dong. "Hierarchically porous Zr-MOFs labeled methylene blue as signal tags for electrochemical patulin aptasensor based on ZnO nano flower." Sensors and Actuators B: Chemical 294 (2019): 192-198.https://doi.org/10.1016/j.snb. 2019.0 5. Baoshan He, Xiaohai Yan, A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, https://doi.org/10.1016/j 6. He, Baoshan, and Xiaoze Dong. "Aptamer based voltammetric patulin assay based on the use of ZnO nanorods." Microchimica Acta 185.10 (2018): 1-8.https://doi.org/10.1007/s00604-018-3006-0 7. Baoshan He, Xiaoze Dong, Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection, Chemical Engineering Journal, Volume 405, 2021, 126642, 8. [IF=5.833] He Baoshan et al."Aptamer based voltammetric patulin assay based on the use of ZnO nanorods."Microchim Acta. 2018 Oct;185(10):1-8 9. [IF=13.273] Baoshan He et al."Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection."Chem Eng J. 2021 Feb;405:126642 10. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B- Chem. 2019 Jul;290:477 11. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B- Chem. 2021 Feb;328:129063 12. [IF=5.833] He Baoshan et al."An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide."Microchim Acta. 2019 Jun;186(6):1-10 13. [IF=5.467] Zhiming Sun et al."Hydrothermal fabrication of rectorite based biocomposite modified by chitosan derived carbon nanoparticles as efficient mycotoxins adsorbents."Appl Clay Sci. 2020 Jan;184:105373 14. [IF=3.223] Min Wei et al."Electrochemical Aptasensor for Zearalenone Based on DNA Assembly and Exonuclease III as Amplification Strategy."Electroanal. 2021 Jul;33(7):1691-1698 15. [IF=1.967] Chenling Qu et al."A homogeneous electrochemical aptasensor based on DNA assembly for zearalenone detection."J Chin Chem Soc-Taip. 2021 Oct;68(10):1998-2005 16. [IF=0.892] Jinping Wu et al."Effects of dietary zearalenone on the serum biochemistry, hepatic and intestinal histology, and intestinal microbiota of juvenile Dabry′s sturgeon (Acipenser dabryanus)."Journal Of Applied Ichthyology. 2021 Oct 04 17. [IF=3.591] Liangrui Lv et al."A switchable electrochemical hairpin-aptasensor for ochratoxin A detection based on the double signal amplification effect of gold nanospheres."New J Chem. 2022 Jan;: 18. [IF=4.932] Weifeng Zhu et al."Hyperoside Attenuates Zearalenone-induced spleen injury by suppressing oxidative stress and inhibiting apoptosis in mice."Int Immunopharmacol. 2022 Jan;102:108408 19. [IF=10.588] Feng Hong et al."A universal, portable and ultra-sensitive pipet immunoassay platform for deoxynivalenol detection based on dopamine self-polymerization-mediated bioconjugation and signal amplification."JOURNAL OF HAZARDOUS MATERIALS. 2022 May;:129257 20. [IF=7.514] Supan Cheng et al."Surface-anchored liquid crystal droplets for the semi-quantitative detection of Aflatoxin B1 in food samples."FOOD CHEMISTRY. 2022 Oct;390:133202 |
BRN 1350216 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Zearalenone | Zearalenone is a mycotoxin with estrogen toxicity produced by fungi such as Gibberella corn, Fusarium graminearum and Fusarium orchid. Zearalenone has strong heat resistance, and it is completely destroyed after lh treatment at lio ° c. Mainly pollute corn, wheat, rice, barley, millet and oats and other grains. Corn has the highest positive detection rate, and it can also pollute livestock and poultry products through words. The effect of zearalenone on animals is similar to estrogen, which can cause too much estrogen. Under the condition of acute poisoning, it will have a toxic effect on the nervous system, heart, kidney, liver and lung. The main mechanism is that it will cause the excitement of the nervous system, cause many bleeding points in the organs, and cause the animal to die suddenly. Pigs are the most sensitive animals to this toxin in all domestic animals, and females are more sensitive than males. Zearalenone intoxication causes slow weight gain in domestic animals, changes in organ weight, decreased fertility, and behavioral abnormalities. It is easy to cause female animals to be infertile, miscarried or weak, resulting in the feminization of male animals. Zearalenone containing 1 mg/kg ~ 5 mg/kg in the word material will affect animals. Zearalenone can also cause symptoms of central nervous system poisoning, such as nausea, chills, headaches, mental depression and ataxia. The limit of zearalenone in grain is 60 yg/kg for wheat and corn. |
| biological activity | Zearalenone is a mycotoxin, mainly produced by Fusarium in food and feed. It has estrogen activity and low acute toxicity in pigs, cattle and sheep. It can cause precocious breast development or other estrogen effects in young sows. |
| Target | Value |
| ERβ () | 165.7 nM |
| ERα () | 240.4 nM |
| use | as veterinary medicine. It is a synthetic growth promoter with estrogen activity and is used as a feed additive. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-rat LD50: 4 mg/kg; Abdominal cavity-mouse LD50: 5 mg/kg |
| stimulation data | skin-guinea pig 50 mg/24 hours severe |
| flammability hazard characteristics | combustible, spicy and irritating smoke from the fire site |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:07
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